Haridus ja eriala

Tallinna Tehnikaülikool, geenitehnoloogia, PhD

Teaduskraadi info

Doktorikraad, 2010, "The Role of Sonic Hedgehog Pathway in Neuro- and Tumorigenesis" ("Sonic Hedgehog signaaliraja roll neurogeneesis ja vähi tekkes"), Tallinna Tehnikaülikool, geenitehnoloogia instituut

Teadustegevuse põhisuunad

Inimeste haiguste modeleerimine in vitro ning nende vastu võimalike ravimite otsimine

Käimasolevad projektid

Borrelia bakterite in vitro uurimine

Valitud publikatsioonid

  • Krishtal J, Metsla K, Bragina O, Tõugu V, Palumaa P. Toxicity of Amyloid-β Peptides varies depending on differentiation route of SH-SY5Y Cells. J Alzheimers Dis. 2019;71(3):879−887.
  • Smirnova J, Kabin E, Järving I, Bragina O, Tõugu V, Plitz T, Palumaa P. Copper(I)-binding properties of de-coppering drugs for the treatment of Wilson disease. α-Lipoic acid as a potential anti-copper agent. Scientific Reports 2018;8(1,1463):1−9.
  • Krishtal J, Bragina O, Metsla K, Palumaa P, Tõugu V. In situ fibrillizing Amyloid-beta 1-42 Induce Neurite Degeneration and Apoptosis of Differentiated SH-SY5Y Cells. PLoS ONE.10.1371/journal.pone.0186636.
  • Bragina O, Gurjanova K, Krishtal J, Kulp M, Karro N, Tõugu V, Palumaa P. Metallothionein 2A affects the cell respiration by suppressing the expression of mitochondrial protein cytochrome c oxidase subunit II. Journal of Bioenergetics and Biomembranes 2015;47(3):209−216.
  • Kulp M, Bragina O. Capillary electrophoretic study of the synergistic biological effects of alkaloids from Chelidonium majus L. in normal and cancer cells. Analytical and Bioanalytical Chemistry 2013;405(10):3391−3397.
  • Sepper R, Prikk K, Metsis M, Sergejeva S, Pugatsjova N, Bragina O, Marran S, Fehniger T. Mucin5B expression by lung alveolar macrophages is increased in long-term smokers. Journal of Leukocyte Biology 2012;92(2):319−324.
  • Kulp M, Bragina O, Kogerman P, Kaljurand M. Capillary electrophoresis with led-induced native fluorescence detection for determination of isoquinoline alkaloids and their cytotoxicity in extracts of Chelidonium majus L. Journal of Chromatography A 2011;1281(31):5298−5304.
  • Bragina O, Sergejeva S, Žarkovsky T, Maloverjan A, Kogerman P, Žarkovsky A. Smoothened agonist augments proliferation and survival of neural cells. Neuroscience Letters 2010;482(2):81−85.
  • Bragina O, Njunkova N, Sergejeva S, Järvekülg L, Kogerman P. Sonic hedgehog pathway activity in prostate cancer.Oncology Letters 2010;1(2):319−327. 
  • Hunt R, Bragina O, Drews M, Kasak L, Timmusk S, Valkna A, Kogerman P, Järvekülg L. Generation and Characterization of mouse monoclonal antibody 5E1 against human transcription factor Gli3. Hybridoma 2007;26:131−138.
  • Speek M, Njunkova O, Pata I, Valdre E, Kogerman P. A potential role of alternative splicing in the regulation of the transcriptional activity of human GLI2 in gonadal tissues. BMC Molecular Biology 2006;7:1−13.
  • Palumaa P, Njunkova O, Pokras L, Eriste E, Sillard R. Evidence for non-isostructural replacement of Zn<2+> with Cd<2+> in the beta-domain of brain-specific metallothionein-3. FEBS Letters 2002;527:76−80.
  • Palumaa P, Eriste E, Njunkova O, Pokras L, Jörnvall H, Sillard R. Brain-specific metallothionein-3 has higher metal-binding capacity than ubiquitous metallothioneins and binds metals noncooperatively. Biochemistry 2002;41:6158−6163.